PC Stats has a rather nice PC building guide that addresses some concerns usually left out of most guides. Like ESD, correct handling, and Installation issues.
Check out the guide
Here
Modern computer systems are designed to be easy to fit together, and they are. The majority of components are keyed so they will only fit a certain way, for one thing, and everything is standardized. This is not to say that it is foolproof, but perhaps foolresistant would be true.